Dry skin treatment with Syndrome Syndrome

Synonyms: dry keratokongunguit, dry syndrome, kserodermatoz etc.

Disease described Swedish optometrist in Sjogren's syndrome 1933 g. Previously (in 1931 g.) a similar clinical picture described with. (A). Spector.

Etiology and pathogenesis

Importance in the evolution of the disease of chronic infection (Sjogren's syndrome), endocrine violations – climacteric, amenorrhea, Ovarian insufficiency, etc..

(E). M. Tareev, Morgen, etc. include dry syndrome to kollagenozam, others consider it a variant of Systemic Lupus Erythematosus. A number of dermatologists see link the disease with vitamin a deficiency of exogenous and endogenous nature. Motitsopoulos and his collaborators believe, Sjogren's syndrome that develops as a result of Lymphocytic Infiltration and blockage of èkkrinnyh glands, leading to reduce or suppress the secretion. Increased concentration of lysozyme in saliva of the parotid glands, in their view, is a specific symptom Syndrome Syndrome.

Clinic

Most dermatologists mark, that "dry" syndrome occurs in middle age, predominantly women menopausal. The clinical picture is characterised by clearly expressed a combination of lesions of the mucous membranes, skin and joints. By eye celebrated xeroftalmia, hyperemia, the conjunctiva and sclera transition. Conjunctiva, dry, patients complain of constant dryness in the eyes: "eyes as if sand buried». Humidity conjunctival sacs very small: "cry without tears".

The mucosa of the mouth is different harsh dryness (xerostomia), often bothered by hoarseness, dry cough, patients cannot swallow food, not squeezed water. Mouth mucosa patent, smooth, often covered with cracks, especially on the tongue and in the corners of the mouth. When far before the process of dry apply to throat, larynx, the trachea, as well as vagina, the urethra and rectum. Often decreases the secretion of the stomach and intestines, that leads to gastritu, kolitu.

Many patients increase Parotid salivary gland. About 50-60% cases indicated defeat type joints of rheumatoid arthritis: pain, deformation joints, muscular atrophy.

Some authors have reported violations of the psyche in the Terminal period of the disease, determinants of depression and sense of fear (anxiety-depression).

Reduced secretion of sweat and sebaceous glands leads to dry skin. The skin loses its normal shine, dims, flakes, There is often follicular Hyperkeratosis, severe itching. The hair becomes dull, fragile, There is hair loss – diffuse or partial. Often affects the nails, they lose their transparency, fade, sometimes significantly thicken due to podnogtevogo Hyperkeratosis.

The disease has a chronic (from a few months to many years) undulating over the; remission, as a rule, There are short-term.

Histopathology

Atrophy of epidermis, smoothing the papillary layer, the absence of basal cells. In the DermIS – Lymphocytic Infiltration. Atrophied appendages.

Differential diagnosis

The differential diagnosis should be performed with Systemic Lupus Erythematosus, nonspecific infectious arthritis, Rheumatoid arthritis, common Seborrheic Eczema, Sarcoidosis.

Treatment

Concurrent long-term corticosteroid combination therapy drugs in normal therapeutic doses with vitamins ((A), complex in, And (e)) and other drugs (rezohin, Analgin, paraaminosalicilovaya acid, etc.); sex hormones, tireoidin, etc. Locally – emollient creams and ointments.

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