Analysis of syphilis Kherson

Nonspecific antiphospholipid (reaginovy) test, the modern equivalent of Wasserman (RW), modification VDRL (Venereal Disease Research Laboratory) test.

RPR – non-treponemal screening test, detect antibodies (реагины) of IgG and IgM antibodies to the lipid material and lipoproteinopodobnomu, released from damaged cells of a patient with syphilis.

RPR test is recommended by the order of MINISTRY OF HEALTH of the RUSSIAN FEDERATION for primary screening and monitoring treatment of syphilis.

Antiphospholipid antibodies, detected by this test, find the 70 – 80% persons with primary syphilis and almost 100% patients with secondary and early latent syphilis. In most cases, the positive response is monitored by RPR 7 – 10 days of later or through the primary 3 – 5 weeks after infection. Titers declined after the onset of the secondary stage of syphilis. About 30% patients with late syphilis become nereaktivnymi on RPR-test. Decrease in RPR titre 4 and the more times during the 1 the year after the therapy proves its efficiency. In 90 – 98% cases of syphilis diagnosed result after the RPR test is negative.

The test is not specific. So sometimes you may experience false positive reactions. Antilipoidnye antibodies can appear not only as a result of syphilis or other treponemnyh infections, but in response to the development of acute or chronic diseases netreponemnyh nature, in which there is tissue damage (especially common in autoimmune diseases).

When you receive a positive result in the RPR test, the patient should be examined dermatovenerologom with repeated blood study using specific diagnostic test treponemnogo (in the laboratory the tornado — test № 70 syphilis by ELISA, antibodies to Treponema pallidum IgG/IgM, identifying specific antibodies to the Antigen of Treponema pallidum).

Rare false negative results in reaction RPR (effect of "prozony" with very high credits reaginovykh antibodies) can be deleted while the appointment test syphilis IgG/IgM ELISA. These two studies are complementary; the combination of RPR test and Elisa IgG/IgM test is the best option for screening to detect or exclude syphilis at all stages.

Features of infection. Syphilis – chronic infectious disease, characterized by a mul′tisistemnym defeat of the organism. Causative agent of syphilis – Treponema pallidum – is unstable in the environment, but well preserved in wet biological materials (sperm, vaginal secret, mucus, pus, etc.). Sexually transmitted, Parenteral, domestic, transplacentarnym paths. Increase the risk of other infections, Sexually Transmitted: herpes, Chlamydia, HPV infection, etc., damage to the mucous membrane of the anal intercourse. Pale treponema has multiple antigens, contributing to the development of antibodies. One of them is the same as kardiolipinu, that allows you to use the latest to detect immunity to pale treponeme.

Infection of the patient may at any stage of syphilis. Most infections are the primary and secondary syphilis if there are active manifestations on the skin and mucous membranes. Pale treponema penetrates through the skin or mucous membranes in the micro-lymphatic vessels, then in the lymph nodes. The pathogen is spread to organs and may be defined in all biological media (saliva, breast milk, sperm, etc.).

In the classical period the incubation period lasts 3 – 4 weeks, primary seronegative – 1 month, then the primary seropositive – 1 month, then the secondary period – 2 – 4 year, the tertiary period. In the primary stage of a hardened Chancre (painless sore or erosion in the bottom place with a dense infiltration of pale Treponema), accompanied by limfangiitom and regional lymphadenitis. At the end of the initial period, the Chancre spontaneously heals, and lymphadenitis is poliadenit and is retained for up to five months.

The first generalized rash is a sign of the beginning of the secondary period. Secondary sifilidy appear in waves (on 1,5 – 2 month each wave) and to disappear. Can be patchy, papuleznymi, pustuleznymi sifilidami, the syphilitic allopeciej (hairloss) and the syphilitic lejkodermoj («Venus» necklace). In the second half of secondary syphilis disappears poliadenit.

The Emergence Of tertiary sifilidov (tubercles and gumm) marks the beginning of the tertiary period, that comes from 40% untreated and treated patients with defective. Tertiary waves separated by longer (sometimes long) latent periods of infection. In affected organs and tissues there are destructive changes. In tertiary sifilidah contains very few treponem, Therefore, they are practically not contagious. Tension immunity falls (t. to. decreases the number of pale treponem), Therefore, it is possible the new infection (resuperinfekciâ).

Transmission of syphilis offspring more likely in the first three years of the disease. As a result, recent miscarriages (on 12 – 16 week), stillbirth, early and late congenital syphilis. Foetal damage most likely on the 5-th month of pregnancy and delivery. Early manifestations of the innate syphilis occur immediately after birth and are similar to the manifestation of secondary syphilis. Sifilidy of late syphilis occurs in the age of the innate 5 – 17 years and similar manifestations of tertiary syphilis. To the absolute grounds is Trine Getčinsona (getčinsonovskie teeth, parenchymal keratitis, labirintnaâ deafness).

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